Exploring Potential Medicinal Materials from Endemic Environments as a Local Wisdom Based Soil Transmitted Helminths (STH) Strategy

Authors

  • Salakory Melianus, Risqa Novita

Abstract

According to the result of research before, control of Soil Transmitted Helminths (STH) can be done with several interventions, namely; It is necessary to carry out integrated research to find risk environments and endemic areas, to form a healthy perception of the community, especially in areas with high risk environments, to carry out mass treatment with a local wisdom-based approach. Mass treatment with a local wisdom approach is intended to encourage the health service seeking behavior of the poor. The method used is this research is pure experimental research with post-test only control group design, preceded by a cross-sectional study design. The result of this research is the identification and activation test of the basic ingredients for worm medicine obtained from the surrounding environment (local wisdom). Fortification of local food ingredients is also carried out using the basic ingredients of worm medicine (local wisdom) which passes the activation test by making snacks from the basic ingredients of sago and cassava and sweet potatoes mixed with basic worm medicine (herbal, non-herbal) and continued with a toxicity test. The results of the toxicity test indicated that: 1) there were no test animals that showed abnormal clinical symptoms during the 13 days of observation for both the treatment and control groups. There were no test animals that died either for the treatment group or for the control group; 2) by testing the Middle Lethal dose (LD50) and there was no significant change in clinical symptoms and did not cause the death of test animals at the maximum dose in which in this study a dose of 2000 mg/kgBB of Paederia scandes, Plumeria acuminate, Leucaena leucocephala extract was used. With pseudo LD 50 because the LD50 obtained is not the real LD50. These results cannot be classified as toxic according to Loomis (1996) criteria. In the Loomis criteria, it is stated that if the maximum dose does not cause death in experimental animals, then the compound is practically non-toxic.

Keywords: medicinal ingredients, environment, endemic, local wisdom.

Published

2020-12-08

Issue

Section

Articles