A Clean, Highly Efficient Synthesis And Antibacterial Activity Of Novel Pyrazole Using Kal(SO4)2.12H2O As Heterogeneous Catalyst Using Ultrasonication

Authors

  • Rajiv Khobare1, Ramkrushna P Pawar, Khandu D Warad, Chandrakant B Mane, Amit Tayade

Abstract

Abstract A clean, highly efficient synthesis and antibacterial activity of novel pyrazole using KAl(SO4)2.12H2O as heterogeneous catalyst was carried out under sonication to afford a substituted pyrazole derivatives with  78-93% of yields. The structure of the synthesized compounds were confirmed on the basis of FTIR, 1H NMR, 13C NMR and MS analysis. The synthesized compounds (1a-j) were assessed for antibacterial activity using different micro-organisms like E. Coli, S. Aureus and Pseudomonas Aerogenosa. Disc diffusion method was used for antibacterial activity on nutrient agar plates. All the compounds showed good antimicrobial activity when compared to standard.   This method has a several advantages over current reaction methodologies, such as shorter reaction times, simple work-up procedure and good percent yields.

Published

2020-12-01

Issue

Section

Articles